Premature ejaculation (PE) is a distressing male sexual dysfunction that can be present from the first sexual encounter or can develop later in life. Men with premature ejaculation appear to go through the same process of ejaculation as other men, but it happens more quickly and with a reduced feeling of control. A combination of physiological and psychological factors is believed to impact on ejaculatory latency. Research suggests that serotonin plays a central role which medicines can help with.